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Selank

Tuftsin, a four-residue fragment of an antibody, with the same Pro-Gly-Pro tail Semax carries. Two different parents, one shared piece of synthetic engineering.

Class
Synthetic heptapeptide (7 residues)
Also written
Tuftsin-Pro-Gly-Pro; TP-7
Molecular formula
C33H57N11O9
Molecular weight
751.9 g/mol
CAS number
129954-34-3
Appearance
White lyophilised powder
Purity specification
99%+ by HPLC
Vial size stocked
10 mg

Sequence

T K P R P G P

Thr-Lys-Pro-Arg-Pro-Gly-Pro. Free at both termini. Thr-Lys-Pro-Arg is tuftsin; Pro-Gly-Pro is the synthetic extension. Four of the seven residues are proline or glycine, which is an unusually rigid backbone for a peptide this short.

Origin

Tuftsin is a naturally occurring tetrapeptide, a fragment of the heavy chain of immunoglobulin G, named for Tufts University where it was first described. Selank was developed at the Institute of Molecular Genetics in Russia by attaching the same Pro-Gly-Pro tail used in Semax. The Pro-Gly-Pro sequence does not occur in immunoglobulin G. The compound is made by synthesis.

Solubility

Freely soluble in water. The lysine and arginine make this a basic peptide — net positive charge across the ordinary working pH range, and better behaved in slightly acidic solution than in alkaline.

Storage and handling

  • Lyophilised powder: store at −20 °C, protected from light and moisture.
  • Bring the vial to room temperature before opening, so condensation does not form on the powder.
  • In solution: refrigerate, protect from light, and treat the working life as far shorter than that of the powder.
  • Avoid repeated freeze-thaw cycles; aliquot first if the solution will be drawn on more than once.
  • Label every reconstituted vial with compound, lot, concentration and date.

How your lot is verified

An independent third-party laboratory tests the material first, then we test it again in-house when it arrives — purity by HPLC, identity by mass spectrometry — and only then does it ship. How we verify.

View Selank 10 mg

Supplied for laboratory research use only. Not for human or veterinary use. No statement on this page has been evaluated by the Food and Drug Administration, and nothing here is intended to diagnose, treat, cure, or prevent any disease. Alpha Aminos is a chemical supplier and does not provide guidance on the use of any compound.

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