Tesamorelin

Forty-four residues with a short unsaturated fatty chain attached at the front. The chain is the whole modification — everything after it is the natural sequence, unchanged.

Class: Synthetic 44-residue peptide, N-terminally acylated and C-terminally amidated
Also written: TH9507; trans-3-hexenoyl-hGRF(1–44)-NH₂
Molecular formula: C₂₂₁H₃₆₆N₇₂O₆₇S
Molecular weight: 5135.9 g/mol
CAS number: 218949-48-5
Appearance: White lyophilised powder
Purity specification: 99%+ by HPLC
Vial size stocked: 10 mg

Structure

trans-3-hexenoyl – [ human GRF 1–44 ] – NH₂

The full 44-residue sequence of human growth hormone-releasing factor, amidated at the C-terminus as the natural hormone is, with a six-carbon unsaturated acyl group — trans-3-hexenoic acid — bonded to the N-terminal tyrosine. That acyl group is the entire difference between tesamorelin and the natural 44-mer, and it is what the name TH9507 identifies. One methionine accounts for the single sulphur.

Origin

Growth hormone-releasing factor is a hypothalamic peptide; its 1–44 amide form is the full-length natural species. Tesamorelin was developed by Theratechnologies. It is made by solid-phase synthesis and the acyl group added chemically — nothing here is extracted from tissue.

Solubility

Soluble in water and in aqueous buffers, though a 44-residue chain hydrates more slowly than a short peptide and rewards patience. The hexenoyl chain adds a hydrophobic head to an otherwise hydrophilic molecule, which is enough to make it more surface-active than its length alone would suggest — another reason not to shake it.

Storage and handling

Lyophilised powder: store at −20 °C, protected from light and moisture.
Direct the diluent down the wall of the vial. A stream driven into the cake will foam this one readily.
In solution: refrigerate, protect from light, and treat the working life as far shorter than that of the powder.
Avoid repeated freeze-thaw cycles; aliquot first if the solution will be drawn on more than once.
Label every reconstituted vial with compound, lot, concentration and date.

How your lot is verified

An independent third-party laboratory tests the material first, then we test it again in-house when it arrives — purity by HPLC, identity by mass spectrometry — and only then does it ship. On a 44-mer the purity number is doing real work: the impurities that matter are deletion sequences one residue short, and they are close enough in mass that the separation, not the spectrum, is what finds them. How we verify.

Ask us to stock Tesamorelin

Supplied for laboratory research use only. Not for human or veterinary use. No statement on this page has been evaluated by the Food and Drug Administration, and nothing here is intended to diagnose, treat, cure, or prevent any disease. Alpha Aminos is a chemical supplier and does not provide guidance on the use of any compound.